The American College of Medical Genetics (2004) recommends that individuals access genetic tests only through an “appropriately qualified health care professional”. This raises questions about a recent wave of genetic tests which are available online and direct-to-consumers (DTC). While examining a variety of genetic mutations and polymorphisms with a range of penetrance and associated risk, the paucity of information on sensitivity, specificity and predictive value makes many DTC genetic test results difficult to interpret and their clinical significance and utility unclear. These tests are accessed online and, in contrast to clinical genetic testing, do not include pre-test or post-test genetic counseling for consumers. Following an ethical analysis of DTC online genetic tests, critical examination highlighted key issues including: (1) the balance of harms and benefits; (2) rights and responsibilities, particularly whether there is an unlimited ‘right to know’ about our genetic make-up; and (3) confidentiality concerns surrounding test results in relation to family members, insurance companies, and employment. Critical analysis of these ethical issues and their implications for individuals, communities, and the wider public and policy decisions were explored.