Much of the discourse surrounding conscience and integrity in bioethics focuses on restrictions, constraints, or prohibitions. The emphasis is on what individuals may not do because our conscience prohibits it or it would violate our integrity. This emphasis seems particularly true in the research context. This presentation will explore a variety of ways in which conscience and integrity inform the conduct of research, decisions about participating in research, and our reliance on research results. Some of these involve decisions researchers might make to avoid particular research practices or areas of research. Others concern decisions patients and family members might make regarding involvement in specific studies. Yet others involve concerns about relying on research results and products that arise from research. The presentation also will shift attention away from the many “don’ts” to developing a positive account of the role conscience and integrity may play in research. It will explore some of the ways in which conscience and integrity may provide a richer account of what we ought to do and not only what we ought not to do.