Nancey Murphy champions a fresh proposal for the ancient body-soul conundrum. According to Murphy, we human beings just are our physical bodies; there is no extra metaphysical substance such as a soul or spirit. All the activities of the ‘mind’ happen at the level of the brain and its nervous system (i.e. ontological reductionism). Yet she denies that poignant dimensions of human life (e.g., our desires, intentions, and hopes) are caused solely by the brain (pace causal reductionism); she also denies that subatomic particles are the only entities that really matter (pace reductive materialism). This nuanced philosophical position is called “nonreductive physicalism.” According to the doctrine of sin, however, we are morally significant creatures and therefore morally blameworthy or accountable before the great God of Israel. Christians have long held that either compatibilist or libertarian freedom grounds this moral responsibility. The present paper briefly evaluates Murphy’s thesis and considers whether it is ultimately consistent with this traditional Christian doctrine of sin.