The tragic cases of British infants Charlie Gard and Alfie Evans received significant international media attention and drew comments from a wide range of influential figures, including President Donald Trump and Pope Francis. Both children had medical conditions characterized by progressive neurological decline which left them dependent on mechanical ventilation for survival. Both were also the subject of extensive legal battles surrounding the authority of the British courts to permit physicians to withhold life-sustaining medical technology the treatment team considered futile over parental objection. This paper analyzes the impact of the well-publicized Charlie Gard and Alfie Evans on Catholic ethics at the end of life. It particularly engages how Catholic end-of-life ethics has not kept pace with secular advances in bioethics on the concept of futility which remain at least partially compatible with existing Church teaching. It also address challenges raised by well-intentioned but problematic legislative efforts at the state level advanced by pro-life advocacy groups in response to these cases.